The Bayou Grand Hotel is a large luxury hotel in Bayou Goula, Louisiana. It was formerly a sanatorium where the artist John James Audubon once recovered from an illness. While there he painted the mysterious painting known as The Black Frame.

Special Agent Pendergast visited the hotel during the events of Fever Dream looking for information about Audubon and the whereabouts of The Black Frame. He found that two others had been there looking for information before him.

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